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Cham, Daniel K. (Herausgeber); Conti, Peter S. (Herausgeber)

PET-CT A Case Based Approach (Kartoniert / Broschiert / Paperback)

Springer New York, November 2010

Softcover reprint of hardcover 1st ed. 2005 - 324 S. - Sprache: Englisch - 279x210x23 mm Previously published in hardcover

ISBN: 1441919279 EAN: 9781441919274

Few advances in medicine have had more of an impact on modern health care than the invention of PET-CT studies of FDG in the living human body and experimental animals. Biochemistry has been superimposed on anatomy, which is a giant leap forward. The expertise required for the interpretation of CT must now be combined with the expert interpretation of the biochemical information of the FDG study. The idea that the interpretation of the images simply requires the superimposition of the two image modalities is simple is clearly not true. What is needed is a clear und- standing of the sites of metabolic activity revealed by FDG studies in normal persons, and its variability from person to person. For example, FDG accumulates in various structures in the head and neck,and in the ovaries and uterus of normal women during certain phases of the menstrual cycle. The case method of teaching has stood the test of time for more than a hundred years and is still valid as new modalities are developed and introduced into medical practice. The authors,both of whom have considerable experience in the performance and interpretation of PET-CT studies with FDG, have made an important contri- tion that will be of great value to nuclear medicine physicians,radiologists,oncologists, and other physicians with the responsibility of caring for patients with cancer. Capabilities and limitations are discussed in the context of speci?c problems and patients.

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The University of Southern California PET Center is recognized as one of the leading PET centers in the world. The director of the USC PET Center, Dr. Peter Conti, is a distinguished leader in the nuclear medicine community. He and one of his top nuclear medicine fellows, Dr. Daniel Cham, will publish the first PET-CT case based book available in the marketplace. The text is heavily illustrated with original detailed PET-CT images of both common and uncommon cancer cases. Each of the clinical applications discussed is accompanied by a comprehensive description of the history, imaging techniques, and the interpretation and impression of the PET-CT case. Additionally, a section on "pearls and pitfalls" and clinical follow-up will help physicians gain a better understanding of the pathology and its changes during growth.


Henry N. Wagner, Jr. Preface......Acknowledgments....Contributing AuthorsContents In Brief...... Part I: The Fundamentals Normal Physiology and Variants: A Primer...........Daniel K. Cham, Peter S. Conti01-01: Normal Physiology01-02: Non-Oncologic Pathology01-03: Post Therapeutic Changes01-04: Foreign Body Artifact01-05: Technical Artifact Part II: Clinical Cases Adrenal Cancer.....Heidi R. Wassef02-01: 72-year-old man with previous resection of right adrenal carcinoma now being evaluated for bulk recurrent disease, evident on recent CT. Germ Cell Tumors: Choricocarcinoma and Testicular Cancer........Anabella S. Din, Peter S. Conti03-01: 25-year-old male status post left orchiectomy with lesions involving the back, mediastinum, abdomen and the left neck, and an elevated beta-HCG and AFP level.03-02: 26-year-old male status post orchiectomy, chemotherapy and radiotherapy.03-03: 55-year-old man status post left orchiectomy, pelvic bone resection and left groin lymph node dissection.03-04: 34-year-old woman with a history of metastatic choriocarcinoma confirmed with nodulectomy during a right thoracotomy, currently presenting with rising HCG. Brain..Sherief Gamie, Peter S. Conti04-01: 75-year-old woman with suspected temporal glioblastoma for recurrence.04-02: 73-year-old male who has a history of brain mass and pulmonary carcinoid.04-03: 81-year-old male who has a history of angiosarcoma.04-04: 38-year-old female with multiple brain lesions.04-05: 46-year-old male who has a history of suprasellar mass now presenting with left eye blindness.04-06: 21-year-old male with a seizure disorder.04-07: 62-year-old female who has a history of glioma.04-08: 53-year-old female with multiple sclerosis and worsening headache for two months. Breast Cancer...Hossein Jadvar 05-01: 53-year-old female with a history of breast cancer and fibrous histiocystoma.05-02: 57-year-old female with a history of left breast cancer, with right pleural and left mid lung metastases.05-03: 48-year-old female with reported small right axillary mass on ultrasound.05-04: 56-year-old female who has a history of breast cancer status post left lumpectomy.05-05: 36-year-old female who has a history of breast cancer and positive neck biopsy. Gynecologic Malignancies: Cervical, Uterine, and Vulvar Cancer .......Hossein Jadvar06-01: 32-year-old female who has a history of cervical cancer and positive pelvic and abdominal lymphadenopathy.06-02: 69-year-old woman with a history of metastatic cervical cancer in the neck and abdomen.06-03: 50-year-old female who has a history of cervical cancer with metastatic disease to lung. 06-04: 32-year-old woman s/p hysterectomy and right oophorectomy for uterine cancer and a left upper lung mass.06-05: 78-year-old female s/p vulvectomy and local radiotherapy for vulvar cancer with a subcutaneous mass in the left groin. Colorectal Cancers.... Robert W. Henderson07-01: 62-year-old male with a history of colon cancer s/p chemotherapy; comparison to positive basal PET study. 07-02: 56-year-old woman with a history of colon CA status post chemotherapy and radiofrequency ablation in the liver, now with rising CEA level.07-03: 59-year-old male status post left hemicolectomy with rising CEA level.07-04: 51-year-old woman with a known metastatic disease for colon carcinoma. 07-05: 42-year-old male with a recent diagnosis of low rectal tumor by biopsy being staged with PET. Cholangiocarcinoma.....Heidi R. Wassef08-01: 74-year-old male who has a history of extrahepatic cholangiocarcinoma s/p Whipple procedure and radioablation therapy now with rising CA 19-9 level.08-02: 60-year-old male with serosal implantation. Esophageal Carcinoma.... Hossein Jadvar, Shahram Bouyadlou09-01: 52-year-old man s/p esophagectomy for esophageal carcinoma currently evaluated for adrenal adenoma versus metastasis.09-02: 51-year-old man with a recent diagnosis of esophageal CA with multiple positive biopsies in the esophagus now with two left upper lobe pulmonary nodules.09-03: 65-year-old male who has a history of esophageal and liver cancer with elevated CEA level.09-04: 63-year-old female status post esophagectomy with gastric pull-up for esophageal carcinoma.09-05: 62-year-old male who has a history of esophageal cancer status post en bloc esophagectomy and gastric pull-up now presenting with dysphasia. Gastric Cancer.........Hossein Jadvar, Shahram Bouyadlou10-01: 64-year-old man with a history of gastric cancer, status post partial gastrectomy with a suspicious lesion in the medial segment of the left hepatic lobe. 10-02: 63-year-old male who has a history of gastric cancer with a suspicious lesion in the medial aspect of the inferior portion of the liver. Gastrointestinal Tumors....Heidi R. Wassef11-01: 43-year-old male who has a history of gastrointestinal stromal tumor.11-02: 67-year-old man with an ulcerative mass in the post-bulbar duodenum. Head and Neck Cancers..........John L. Go12-01: 35-year-old woman who is status post left modified radical neck dissection with a diagnosis of buccal cavity squamous cell carcinoma. 12-02: 62-year-old male who has a history of squamous cell carcinoma on the face with the most recent MR demonstrating suspicious lesions involving the right lateral pons, right internal auditory canal, and left infratemporal fossa. 12-03: 44-year-old woman with a history of nasopharyngeal carcinoma. 12-04: 63-year-old male presents with an enlarged left neck lymph node and a right upper jaw pain. 12-05: 50-year-old male who has a history of oral squamous cell carcinoma status post resection. 12-06: 44-year-old woman who had a diagnosis of palate carcinoma with a right infratemporal fossa tumor recurrence on MR.12-07: 73-year-old man with a history of soft palate surgery status post maxillary sinus surgery.12-08: 59-year-old male who has a history of right parotid cancer follow by resection. 12-09: 72-year-old male who has a history of squamous cell carcinoma involving the right parotid gland status post reconstructions. 12-10: 51-year-old male who has a history of tonsillar and submandibular cancer later treated with radiation therapy. Heart Viability..Lalitha Ramanna13-01: 55-year-old male with a history of coronary artery disease status post CABG evaluation for heart viability.13-02: 73-year-old female status post myocardial infarction demonstrating a transmural infarction on a thallium scan and mild to moderate ischemia in the inferoposterior wall. Inflammatory Disease and Infection......Lalitha Ramanna14-01: 77-year-old female with a history of ulcerative colitis presents with significant dilatation in the biliary ducts and colon. Unknown Primary Tumors ...Shahram Bouyadlou, Peter S. Conti15-01: 38-year-old male who has a history of low-grade fever and episodic night sweats.15-02: 44-year-old male who has a history of an inflamed left buttock. Liver Cancer.....Heidi R. Wassef16-01: 67-year-old male who has a history of hepatic ductal cancer.16-02: 68-year-old male s/p liver transplant with suspicious lesions on MR involving the right hepatic dome and right posterior lobe of the liver.16-03: 59-year-old male s/p liver transplant with rising AFP level.16-04: 58-year old male with rising AFP level.16-05: 41-year-old with cirrhosis secondary to hepatitis-B and hepatoma being evaluated for potential liver transplant. Lung Tumors...........Hossein Jadvar, Sherief Gamie17-01: 57-year-old man with known right-sided malignant mesothelioma. 17-02: 55-year-old male who has a history of lung cancer status post left lung biopsy with suspected metastases in the brain and kidney.17-03: 85-year-old female who has a large mass in the left mid lung and lymphadenopathy in the left hilum, subcarcina, and azygo-esophageal space on a recent chest CT.17-04: 59-year-old male who has a history of lung cancer with a large mass in the right upper lobe and supraclavicular adenopathy. 17-05: 72-year-old female who has a history of lung cancer positive on bronchoscopy.17-06: 65-year-old man with known oat cell carcinoma being evaluated for restaging. Hematologic Malignancies: Lymphoma, Leukemia, Multiple Myeloma Robert W. Henderson18-01: 67-year-old male s/p left neck biopsy proven to be lymphoma being staged with PET.18-02: 62-year-old female with several suspicious nodules in the abdominal cavity.18-03: 64-year-old female with a recent diagnosis of lymphoma being staged with PET.18-04: 47-year-old man with diagnosis of plasmocytoma with subsequent proton therapy status post decompressive laminectomy.18-05: 42-year-old man with a history of acute myelocytic leukemia with a left neck lymph node biopsy inconclusive for malignancy.18-06: 27-year-old female who has a history of Castleman's Diseases presented with retroperitoneal adenopathy.18-07: 58-year-old male presents with several suspicious lesions involving the lung, liver, and spleen. Melanoma.Heidi R. Wassef19-01: 69-year-old woman with a history of right heel melanoma and right inguinal lymph node involvement.19-02: 75-year-old male with abnormal CT in the rib, liver and lungs bilaterally.19-03: 75-year-old woman who has Stage-III melanoma s/p ipsilateral right inguinal lymph node dissection. Thyroid Carcinoma Lalitha Ramanna20-01: 74-year-old woman s/p thyroidectomy and radioablation presenting with elevating thyroglobulin level.20-02: 49-year-old female with a history of papillary thyroid cancer s/p radiotherapy and limited neck dissection.20-03: 62-year-old male with an undifferentiated thyroid carcinoma and esophageal cancer s/p radiotherapy and chemotherapy.20-04: Remote history of thyroid carcinoma is now being evaluated for soft tissue near the thyroid area suspicious for recurrence. Muscular Skeletal Tumors.....Lalitha Ramanna, Sherief Gamie21-01: 52-year-old female has a sarcoma in the right thigh. 21-02: 80-year-old with a leiomyosarcoma.21-03: 19-year-old male who has a history of a left ankle mass positive for osteosarcoma.21-04: 43-year-old female has a right thigh angiosarcoma being evaluated for recurrence.21-05: 25-year-old male who has a history of right knee mass increasing in size. Urinary Malignancies: Renal Cell Carcinoma, Bladder Cancer....Lalitha Ramanna22-01: 55-year-old male who has a history of renal cell carcinoma s/p left nephrectomy and chemotherapy with a new left renal mass and a nodule in the right lower lung field.22-02: 76-year-old man with a remote history of laryngeal cancer and a recently diagnosed renal cell carcinoma. 22-03: 82-year-old man s/p left nephrectomy and cystectomy for bladder cancer currently being evaluated for a new chest mass. Nerve Tumor....Lalitha Ramanna23-01: 63-year-old female who has high-grade malignant peripheral nerve sheath tumor of the right facial nerve with recent fine needle aspiration of a right middle lobe mass positive for malignant spindle cell.23-02: 48-year-old male s/p right ulnar mass resection with primitive neuroectodermal tumor (PNET). 23-03: 39-year-old male with Schwannoma and multiple left inguinal resections.23-04: 32-year-old male presents with a left calf tumor, evaluation for metabolic activity and metastatic disease is requested. Ovarian Cancer.Hossein Jadvar24-01: 73-year-old female status post right gluteal resection from sarcoma who presents with a new right iliac mass.24-02: 74-year-old female with rising CA-125 leveled s/p hysterectomy, bilateral salpingo oophorectomy, and omentectomy and positive pelvic washing. 24-03: 69-year-old female with a history of ovarian cancer currently on Cytoxan therapy. Pancreatic Cancer.....Heidi R. Wassef25-01: 47-year-old male with a history of pancreatic cancer and liver lesions on CT.25-02: 82-year-old male with fullness in the pancreatic head on CT and bilateral cavitated pulmonary nodules. 25-03: 64-year-old woman with a history of pancreatic cancer ten years ago, status-post Whipple procedure along with a history of thyroidectomy for thyroid cancer eight years ago. Prostate Cancer.......Hossein Jadvar26-01: 50-year-old man has a prevertebral soft tissue at T-9 on CT and urinary tract symptoms. 18F-Fluoride Bone Scintigraphy. .........Peter S. Conti27-01: 37-year-old male with a history of osteosarcoma. References........ Appendix.. Reimbursement. ...Jennifer S. Keppler Index...


From the reviews: "The editors of this timely volume have got together a group of contributors and produced a highly educational resource for the practising radiologist. All types of cancer are covered, including excellent sections on the brain, gynaecological malignancies, oesophageal cancer, lung tumours etc. The production of the book is excellent with excellent layout and beautiful, high quality images throughout. The pearls and pitfalls sections in each case are particularly useful, as is the discussion. I have found reading this book an invaluable introduction to this new clinical tool. It should be required reading for all who are embarking on clinical practice in this area and also for others who are interested in its application in oncology. The textbook deserves to be a success and a standard introductory textbook in this field." (RAD Magazine, September, 2005) "This book ... is extremely timely, given the great success and rapid diffusion of PET-CT. ... The authors, supported by numerous qualified co-workers, have used their considerable experience in the performance and interpretation of PET-CT ... . The entire field of application, from the brain to gynaecological pathology, is considered clearly and comprehensively. ... this book will be of value not only to beginners and/or residents but also to experts ... ." (U. P. Guerra and L. Mansi, European Journal for Nuclear Medicine and Molecular Imaging, Vol. 33, 2006) "This is an up to the minute text demonstrating state of the art dedicated PET-CT studies. ... The book is extremely well presented. ... There are 472 illustrations ... . these figures are of an excellent standard and make this an enjoyable and valuable text. ... The book is well indexed and easy to navigate. ... The case study formula is well designed and makes this textbook a pleasurable book to 'dip' into ... . this is a delightful book of PET-CT case studies." (Kevin Bradley, Neuroradiology, Vol. 47 (11), 2005) "The book is organized in a 'case-based' format with the intention of providing clinical examples of state-of-the-art positron emission tomography-computed tomography (PET/CT) imaging for all diagnostic PET practitioners (in radiology, nuclear medicine, and oncology), from the novice to the experienced reader. ... The book is well written and well organized. ... All practitioners, from novices to experts, would benefit from the variety of cases presented." (Suzanne Mastin, Radiology, Vol. 243 (3), 2007)

ISBN 1-441919-27-9, ISBN 1-44-191927-9, ISBN 1-44191-927-9, ISBN 1-441-91927-9, ISBN 1-4419-1927-9

ISBN 978-1-441919-27-4, ISBN 978-1-44-191927-4, ISBN 978-1-44191-927-4, ISBN 978-1-441-91927-4, ISBN 978-1-4419-1927-4

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