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Brack, Werner (Herausgeber)

Effect-Directed Analysis of Complex Environmental Contamination (Gebundene Ausgabe)

Reihe: Handbook of Environmental Chemistry 15

Springer-Verlag GmbH, Springer Berlin, April 2011

340 S. - Sprache: Englisch - 243x164x25 mm Book

ISBN: 3642183832 EAN: 9783642183836

Today more than 5 million chemicals are known and roughly 100,000 of them are frequently used, with both numbers rising. Many of these chemicals are ultimately released into the environment and may cause adverse effects to ecosystems and human health. Effect-directed analysis (EDA) is a promising tool for identifying predominant toxicants in complex, mostly environmental mixtures combining effect testing, fractionation and chemical analysis. In the present book leading experts in the field provide an overview of relevant approaches and tools used in EDA. This includes diagnostic biological tools, separation techniques and advanced analytical and computer tools for toxicant identification and structure elucidation. Examples of the successful application of EDA are discussed such as the identification of mutagens in airborne particles and sediments, of endocrine disruptors in aquatic ecosystems and of major toxicants in pulp and paper mill effluents. This book is a valuable, comprehensive and interdisciplinary source of information for environmental scientists and environmental agencies dealing with the analysis, monitoring and assessment of environmental contamination.

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A comprehensive reviewWritten by expertsAn invaluable source of information for environmental scientists and environmental agencies dealing with the analysis, monitoring and assessment of environmental contamination


Early Evolution of the Toxicity Identification Evaluation Process: Contributions from the United States Environmental Protection Agency Effluent Testing Program Gerald T. Ankley, James R. Hockett, Donald I. Mount, David R. MountRecent Developments in Whole Sediment Toxicity Identification Evaluations (TIEs): Innovations in Manipulations and Endpoints Robert M Burgess, Kay T Ho, Adam D Biales, Werner BrackConsiderations for Incorporating Bioavailability in Effect-Directed Analysis and Toxicity Identification Evaluation Werner Brack, Robert M BurgessDiagnostic tools for Effect-Directed Analysis of mutagens, AhR agonists and endocrine disruptors Gisela Umbuzeiro, Miroslav Machala, Jana WeissSeparation Techniques in Effect-Directed Analysis Werner Brack, Nadin Ulrich, Mahmoud BatainehSimultaneous screening and chemical characterization of bioactive compounds using LC-MS based technologies (affinity chromatography) Martin Giera and Hubertus IrthAdvanced GC-MS and LC-MS tools for structure elucidation in effect-directed analysis Pim Leonards, Rikke Brix, Damià Barceló, and Marja LamoreeComputer Tools for Structure Elucidation in Effect-Directed Analysis Emma Schymanski, Tobias Schulze, Jos Hermans and Werner BrackEffect-directed analysis of mutagens in ambient airborne particles John L. Durant and Arthur L. LafleurEffect-Directed Analysis of endocrine disruptors in aquatic ecosystems Corine J. Houtman, Juliette Legler, Kevin ThomasEffects-directed studies of pulp and paper mill effluents Mark HewittEffect-directed analysis of Ah-receptor mediated toxicants, mutagens and endocrine disruptors in sediments and biota Markus Hecker and John P. GiesyEcological relevance of key toxicants in aquatic systems Mechthild Schmitt-Jansen, Peter von der Ohe, Stephanie Franz, Stefanie Rotter, Sergi Sabater, Dick de Zwart, Helmut Segner

ISBN 3-642-18383-2

ISBN 978-3-642-18383-6

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