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DiStefano, Johanna K. (Herausgeber)

Disease Gene Identification Methods and Protocols (Gebundene Ausgabe)


Reihe: Methods in Molecular Biology 700

Springer-Verlag GmbH, Humana Press, Februar 2011


310 S. - Sprache: Englisch - 43 schwarz-weiße Abbildungen, 31 schwarz-weiße Tabellen - 268x187x24 mm

ISBN: 1617379530 EAN: 9781617379536

Recent efforts to characterize genetic variation in the human genome, coupled with the rapidly developing field of genomics, have lead directly to the development of new and innovative approaches to the identification of genes contributing to complex human diseases. In Disease Gene Identification: Methods and Protocols, expert researchers in the field provide up-to-date molecular methodologies used in the process of identifying a disease gene, from the initial stage of study design to the next stage of preliminary locus identification, and ending with stages involved in target characterization and validation. As a volume in the highly successful Methods in Molecular Biology(TM) series, chapters contain brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and detailed tips on troubleshooting and avoiding known pitfalls. Authoritative and essential, Disease Gene Identification: Methods and Protocols seeks to aid scientists striving toward the identification and characterization of the many disease-related genes, which may someday pave the way for more accurate and improved methods of disease diagnosis as well as vital strategies for disease treatment and prevention.


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Produktdetails

-Presents detailed laboratory procedures in an easy-to-follow format, accessible to graduate students, post-doctoral researchers, and bench scientists -Features readily reproducible protocols along with tips on troubleshooting -Feeds upon expert personal experience to ensure successful implementation

Inhaltsverzeichnis

Part I: Introduction 1. Technological Issues and Experimental Design of Gene Association Studies Johanna K. DiStefano and Darin M. Taverna 2. Statistical Issues in Gene Association Studies Richard M. Watanabe 3. Identification of Causal Sequence Variants of Disease in the Next Generation Sequencing Era Christopher B. Kingsley Part II: Methods for Gene Identification 4. Microarray-Based Genome-Wide Association Studies Using Pooled DNA Szabolcs Szelinger, John V. Pearson, and David W. Craig 5. Medium-Throughput SNP Genotyping Using Mass Spectrometry: Multiplex SNP Genotyping Using the iPLEX? Gold Assay Meredith P. Millis 6. Targeted SNP Genotyping Using the TaqMan? Assay Dorit Schleinitz, Johanna K. DiStefano, and Peter Kovacs 7. Bar-Coded, Multiplexed Sequencing of Targeted DNA Regions Using the Illumina Genome Analyzer Szabolcs Szelinger, Ahmet Kurdoglu, and David W. Craig Part III: Functional Characterization of Susceptibility Alleles and Loci 8. Site-Directed Mutagenesis Patricia E. Carrigan, Petek Ballar, and Sukru Tuzmen 9. Gene Expression Profiling of Tissues and Cell Lines: A Dual Color Microarray Method Sonsoles Shack 10. Methods for microRNA Microarray Profiling Aarati R. Ranade and Glen J. Weiss 11. Allelic Expression Profiling to Dissect Genome-Wide Association Study Signals Jonathan D. Gruber 12. Quantitative Polymerase Chain Reaction: Quantitative PCR Using the Comparative Cq Method Kimberly Yeatts 13. Genomic Analysis by Oligonucleotide Array Comparative Genomic Hybridization Utilizing Formalin-Fixed Paraffin Embedded Tissues Stephanie J. Savage and Galen Hostetter 14. RNA Mapping Protocols: Northern-Blot and Amplification of cDNA Ends Maria Lucrecia Alvarez and Mahtab Nourbakhsh 15. High Content RNA Interference Assay: Analysis of Tau Hyperphosphorylation as a Generic Paradigm RiLee H. Robeson and Travis Dunckley Part IV: Alternative Approaches 16. Integrative Systems Biology Approaches to Identify and Prioritize Disease and Drug Candidate Genes Vivek Kaimal, Divya Sardana, Eric E. Bardes, Ranga Chandra Gudivada, Jing Chen, and Anil G. Jegga 17. Identification of a Common Variant Affecting Human Episodic Memory Performance Using a Pooled Genome-Wide Association Approach: A Case Study of Disease Gene Identification Traci L. Pawlowski and Matthew J. Huentelman 18. RNAi-Based Functional Pharmacogenomics Sukru Tuzmen, Pinar Tuzmen, Shilpi Arora, Nathalie Meurice, Spyro Mousses, and David Azorsa 19. Genetic Predisposition to ß-Thalassemia and Sickle Cell Anemia in Turkey: A Molecular Diagnostic Approach A. Nazli Basak and Sukru Tuzmen

Kritikerstimmen

From the reviews:"This is an excellent resource for innovative approaches to the identification of genes contributing to complex human diseases. ... presenting detailed laboratory procedures in an easy-to-follow format that can be carried out successfully by competent experts lacking exposure to a specific research method. ... will be useful for clinicians such as oncologists interested in learning about gene identification. ... an excellent resource for graduate students, postdoctoral researchers, bench scientists, clinical oncologists, and hematologists interested in the fields of molecular genetics and molecular biology." (Omer Iqbal, Doody's Review Service, June, 2011)


ISBN 1-617379-53-0, ISBN 1-61-737953-0, ISBN 1-61737-953-0, ISBN 1-617-37953-0, ISBN 1-6173-7953-0

ISBN 978-1-617379-53-6, ISBN 978-1-61-737953-6, ISBN 978-1-61737-953-6, ISBN 978-1-617-37953-6, ISBN 978-1-6173-7953-6

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