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Reidys, Christian

Combinatorial Computational Biology of RNA Pseudoknots and Neutral Networks (Gebundene Ausgabe)

Springer-Verlag GmbH, Springer US, November 2010


257 S. - Sprache: Englisch - 70 schwarz-weiße und 53 farbige Abbildungen, 23 schwarz-weiße Tabellen - 244x161x25 mm

ISBN: 0387767304 EAN: 9780387767307

In this monograph, new combinatorial and computational approaches in the study of RNA structures are presented which enhance both mathematics and computational biology. It begins with an introductory chapter, which motivates and sets the background of this research. In the following chapter, all the concepts are systematically developed. The reader will find * integration of more than forty research papers covering topics like, RSK-algorithm, reflection principle, singularity analysis and random graph theory * systematic presentation of the theory of pseudo-knotted RNA structures including their generating function, uniform generation as well as central and discrete limit theorems * computational biology of pseudo-knotted RNA structures, including dynamic programming paradigms and a new folding algorithm * analysis of neutral networks of pseudo knotted RNA structures and their random graph theory, including neutral paths, giant components and connectivity All algorithms presented are freely available through springer.com and implemented in C. A proofs section at the end contains the necessary technicalities. This book will serve graduate students and researchers in the fields of discrete mathematics, mathematical and computational biology. It is suitable as a textbook for a graduate course in mathematical and computational biology.


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Produktdetails

Presents new combinatorics and combinatorial structures and applies them to the study of RNA structures Presents new results on pseudoknot RNA Motivating introductory chapter

Inhaltsverzeichnis

Introduction.- Secondary Structures, Pseudoknot RNA and Beyond.- Folding Sequences into Structures.- Evolution of RNA Sequences.- Methods.- References.- Index.

Kritikerstimmen

From the reviews: "This book is devoted to the study of the structure of combinatorial models of the ribonucleic acid (RNA). ... This book can serve as an introduction to the study of combinatorial computational biology as well as a reference of known results and state of the art in this topic." (Ludovit Niepel, Zentralblatt MATH, Vol. 1207, 2011)


ISBN 0-387767-30-4, ISBN 0-38-776730-4, ISBN 0-38776-730-4, ISBN 0-387-76730-4, ISBN 0-3877-6730-4

ISBN 978-0-387767-30-7, ISBN 978-0-38-776730-7, ISBN 978-0-38776-730-7, ISBN 978-0-387-76730-7, ISBN 978-0-3877-6730-7

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