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Hurst, Sarah J. (Herausgeber)

Biomedical Nanotechnology Methods and Protocols (Gebundene Ausgabe)

Humana Press, Humana Press Inc., April 2011

2011 - 448 S. - Sprache: Englisch - 262x189x30 mm Book

ISBN: 1617790516 EAN: 9781617790515

Due to their unique size-dependent properties, nanomaterials have the potential to revolutionize the detection, diagnosis, and treatment of disease by offering superior capabilities compared to conventionally-used materials.  Biomedical Nanotechnology: Methods and Protocols brings together experts from a wide variety of fields to provide a practical overview of biomedical nanotechnology, from the conception of novel materials in the laboratory to the application of such structures in the clinic. After a brief introductory chapter, the first section consists of protocol chapters which provide hands-on information on the synthesis of a variety of solution-phase and surface-bound nanomaterials and their application in sensing, imaging, and/or therapeutics, while the second section consists of a series of case studies and review chapters that discuss the toxicology of nanomaterials, the regulatory pathways to US Food and Drug Administration (FDA) approval of these materials, their patenting, marketing, and commercialization, and the legal and ethical issues surrounding their use.  Written in the highly successful Methods in Molecular Biology(TM) series format, many chapters include introductions to their respective topics, lists of the necessary materials, step-by-step, readily reproducible protocols, and insightful tips on troubleshooting and avoiding known pitfalls.  Cutting-edge and authoritative, Biomedical Nanotechnology: Methods and Protocols surveys this exciting field from the most vital angles in order to provide a comprehensive reference for scientists and researchers of all different backgrounds looking to utilize the numerous versatile applications of nanomaterial technologies.

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Provides versatile nanoparticle bioconjugation strategies and a comprehensive view of the use of nanomaterials in biomedicineContains case studies on the translation of nanomaterials to the clinicIncludes expert tips and vital implementation advice


1. Biomedical Nanotechnology            Sarah J. Hurst Part I: Using Nanomaterials in Sensing, Imaging, and Therapeutics 2. Multiplexed Detection of Oligonucleotides with Biobarcoded Gold Nanoparticle Probes            Jae-Seung Lee 3. Molecular Detection of Biomarkers and Cells Using Magnetic Nanoparticles and Diagnostic Magnetic Resonance            Jered B. Haun, Tae-Jong Yoon, Hakho Lee, and Ralph Weissleder 4. Real-Time Quantum Dot Tracking of Single Proteins            Jerry C. Chang and Sandra J. Rosenthal 5. Titanium Dioxide Nanoparticles in Advanced Imaging and Nanotherapeutics            Tijana Rajh, Nada M. Dimitrijevic, and Elena A. Rozhkova 6. Surface Modification and Biomolecule Immobilization on Polymer Spheres for Biosensing Applications            Chris R. Taitt, Lisa C. Shriver-Lake, George P. Anderson, and Frances S. Ligler 7. Multivalent Conjugation of Peptides, Proteins, and DNA to Semiconductor Quantum Dots            Duane E. Prasuhn, Kimihiro Susumu, and Igor L. Medintz 8. A Single SnO2 Nanowire-Based Microelectrode            Jun Zhou, Yaguang Wei, Qin Kuang, and Zhong Lin Wang 9. Biosensing Using Nanoelectromechanical Systems (NEMS)            Ashish Yeri and Di Gao 10. Nano "Fly Paper" Technology for the Capture of Circulating Tumor Cells            Shutao Wang, Gwen E. Owens, and Hsian-Rong Tseng 11. Polymeric Nanoparticles for Photodynamic Therapy            Yong-Eun Koo Lee and Raoul Kopelman 12. Hydrogel Templates for the Fabrication of Homogeneous Polymer Microparticles            Ghanashyam Acharya, Matthew McDermott, Soo Jung Shin, Haesun Park, and Kinam Park 13. Antibacterial Application of Engineered Bacteriophage Nanomedicines: Antibody-Targeted, Chloramphenicol Prodrug Loaded Bacteriophages for Inhibiting the Growth of Staphylococcus aureus Bacteria            Lilach Vaks and Itai Benhar 14. Viruses as Nanomaterials for Drug Delivery            Dustin Lockney, Stefan Franzen, and Steven Lommel 15. Applications of Carbon Nanotubes in Biomedical Studies            Hongwei Liao, Bhavna Paratala, Balaji Sitharaman, and Yuhuang Wang 16. Electrospun Nanofibrous Scaffolds for Engineering Soft Connective Tissues            Roshan James, Udaya S. Toti, Cato T. Laurencin, and Sangamesh G. Kumbar 17. Peptide Amphiphiles and Porous Biodegradable Scaffolds for Tissue Regeneration in the Brain and Spinal Cord            Rutledge G. Ellis-Behnke and Gerald E. Schneider 18. Computational Simulations of the Interaction of Lipid Membranes with DNA-Functionalized Gold Nanoparticles            One-Sun Lee and George C. Schatz Part II: Translating Nanoscience and Technology from the Lab to the Clinic 19. Cytotoxic Assessment of Carbon Nanotube Interaction with Cell Cultures            Hanene Ali-Boucetta, Khuloud T. Al-Jamal, and Kostas Kostarelos 20. Nanoparticle Toxicology:  Measurements of Pulmonary Hazard Effects Following Exposures to Nanoparticles            Christie M. Sayes, Kenneth L. Reed, and David B. Warheit 21. Nanoparticle Therapeutics: FDA Approval, Clinical Trials, Regulatory Pathways, and Case Study            Aaron C. Eifler and C. Shad Thaxton 22. Legislating the Laboratory?: Promotion and Precaution in a Nanomaterials Company            Robin Phelps and Erik Fisher 23. Navigating the Patent Landscapes for Nanotechnology: English Gardens or Tangled Grounds?            Douglas J. Sylvester and Diana M. Bowman 24. Scientific Entrepreneurship in the Materials and Life Science Industries            Jose Amado Dinglasan, Darren J. Anderson, and Keith Thomas 25. Applying the Marketing Mix (5 P's) to Bionanotechnology            Michael S. Tomczyk 26. Managing the "Known Unknowns": Theranostic Cancer Nanomedicine and Informed Consent            Fabrice Jotterand and Archie A. Alexander

ISBN 1-617790-51-6, ISBN 1-61-779051-6, ISBN 1-61779-051-6, ISBN 1-617-79051-6, ISBN 1-6177-9051-6

ISBN 978-1-617790-51-5, ISBN 978-1-61-779051-5, ISBN 978-1-61779-051-5, ISBN 978-1-617-79051-5, ISBN 978-1-6177-9051-5

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