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Alessio, Enzo (Herausgeber)

Bioinorganic Medicinal Chemistry (Gebundene Ausgabe)

Wiley VCH Verlag GmbH, Wiley-VCH Verlag GmbH & Co. KGaA, Januar 2011


422 S. - Sprache: Englisch - 131 schwarz-weiße und 19 farbige Abbildungen, 15 schwarz-weiße Tabellen - 252x182x27 mm

ISBN: 3527326316 EAN: 9783527326310

Edited by a renowned and experienced lecturer, this handbook and reference provides an in-depth overview of this key area in medicine and bioinorganic chemistry, detailing such topics as targeting strategies, mechanism of action, Pt-based antitumor drugs and radiopharmaceuticals.


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Inhaltsverzeichnis

MEDICINAL INORGANIC CHEMISTRY: STATE OF THE ART, NEW TRENDS, AND A VISION OF THE FUTURE Introduction Antimicrobial Agents Antiviral Agents Systemic and Metabolic Diseases Including Inflammation Metal Chelating Agents Antiarthritic Drugs and Inflammation Bipolar Disorder Anticancer Agents Small Molecule Delivery and Control Diagnostic Agents Veterinary Medicinal Inorganic Chemistry Conclusions and Vision TARGETING STRATEGIES FOR METAL-BASED THERAPEUTICS Introduction Physiological Targeting Molecular Targeting Immunological Targeting Concluding Remarks CURRENT STATUS AND MECHANISM OF ACTION OF PLATINUM-BASED ANTICANCER DRUGS Introduction Mechanism of Action of Cisplatin Limitations of Current Platinum-Based Compounds: New Strategies Novel Concepts in the Development of Platinum Antitumor Drugs Concluding Remarks NEW TRENDS AND FUTURE DEVELOPMENTS OF PLATINUM-BASED ANTITUMOR DRUGS Introduction Mechanisms of Action and Resistance Monofunctional Platinum(II) Complexes Trans-Platinum(II) Complexes Multinuclear Platinum(II) C omplexes Platinum(IV) Complexes Delivery of Platinum Drugs Concluding Remarks and Future Perspectives RUTHENIUM AND OTHER NON-PLATINUM ANTICANCER COMPOUNDS Introduction Ruthenium Anticancer Compounds From Gallium Nitrate to Oral Gallium Complexes Titanium Anticancer Compounds Ferrocene-Derived Anticancer Agents The Main Group Organometallics Spirogermanium and Germanium-132 Arsenic in Cancer Chemotherapy Overcoming the Resistance of Tumors to Anticancer Agents by Rare Earth Element Compounds Conclusions THE CHALLENGE OF ESTABLISHING RELIABLE SCREENING TESTS FOR SELECTING ANTICANCER METAL COMPOUNDS Introduction Tumor Cell Growth Inhibition and Cell Death Screening Assays Metal-Based Anticancer Compounds and Gene Expression Microarray Technologies Metal-Based Anticancer Compounds and the Proteomic Approach Concluding Remarks GOLD-BASED THERAPEUTIC AGENTS: A NEW PERSPECTIVE Introduction Biological Chemistry of Gold Gold Antiarthritic Drugs Gold Complexes as Anticancer Agents Gold Complexes as Antiparasitic Agents Concluding Remarks MRI CONTRAST AGENTS: STATE OF THE ART AND NEW TRENDS Introduction T1 Agents T2-Susceptibility Agents CEST Agents Concluding Remarks METAL-BASED RADIOPHARMACEUTICALS Introduction Selected Examples: Therapeutic Radiopharmaceuticals Diagnostic Metal-Based Radiopharmaceuticals Perspectives and Conclusion BORON AND GADOLINIUM IN THE NEUTRON CAPTURE THERAPY OF CANCER Introduction Boron Neutron Capture Therapy Role of Medicinal Inorganic Chemistry in BNCT Gadolinium Neutron Capture Therapy Conclusions and Future Outlook ESSENTIAL METAL RELATED METABOLIC DISORDERS Introduction: What is Essentiality? Iron Metabolic Diseases: Acquired and Genetic Copper Metabolic Diseases Zinc Metabolic Diseases Diseases Related to Imbalances in Electrolytic Metabolism: P, the Alkali Metals, and the Alkaline Earths Metabolism of Other Trace Elements Conclusions METAL COMPOUNDS AS ENZYME INHIBITORS Introduction Kinase Inhibitors Proteasome Inhibitors Carbonic Anhydrase Inhibitors (CAIs) Cyclooxygenase Inhibitors Acetylcholinesterase Inhibitors Protein Phosphatase Inhibitors Trypsin and Thrombin Inhibitors Cysteine Protease Inhibitors and Glutathione Transferase Inhibitors HIV-1 Reverse Transcriptase and Protease Inhibitors Telomerase Inhibitors Zinc Finger Protein Inhibitors CXCR4 Inhibitors Xanthine Oxidase Inhibitors Miscellaneous Protein Inhibitors and Conclusions BIOMEDICAL APPLICATIONS OF METAL-CONTAINING LUMINOPHORES Introduction: Luminescence in Diagnostics and Imaging Transition-Metal Containing Luminescent Agents Lanthanide-Based Luminophores Nanoparticle-Based Luninophores Conclusions and Perspectives

Über den Autor

Enzo Alessio was born in 1958, studied chemistry at the University of Trieste (Italy) and received his PhD from the University of Ferrara (Italy) in 1989. After a NATO-CNR postdoctoral fellowship with Luigi G. Marzilli at Emory University (Atlanta), he became fi rst Research Associate and then Associate Professor of Inorganic Chemistry at the University of Trieste, where he is now director of the PhD School in Chemistry. He is co-author of more than 150 publications and 10 patents in the fi elds of coordination chemistry, metal-based anticancer drugs, and metal-driven construction of supramolecular architectures, in particular multi-chromophore assemblies for photophysical applications.

Kritikerstimmen

"Expert readers looking for an up-to-date overview of recent developments in their field of research as well as doctoral students with a certain background knowledge in bioinorganic chemistry entering this highly interdisciplinary and quickly advancing field are the main audience for this well-edited book and will benefit from the concise treatment as well as the many references to highly topical primary publications."Angewandte Chemie, November 2011 doi:10.1002/anie.201104828


ISBN 3-527-32631-6

ISBN 978-3-527-32631-0

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