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Yona, Simon (Herausgeber); Stacey, Martin (Herausgeber)

Adhesion-GPCRs Structure to Function (Gebundene Ausgabe)

Reihe: Advances in Experimental Medicine and Biology 706

Springer-Verlag GmbH, Springer US, New York, N.Y., April 2011

200 S. - Sprache: Englisch - 40 schwarz-weiße Abbildungen, 10 schwarz-weiße Tabellen - 267x189x18 mm

ISBN: 1441979123 EAN: 9781441979124

The field of adhesion-GPCR biology has indeed become large enough to require a volume dedicated solely to this field. The contributors to this book have made a courageous effort to address the key concepts of adhesion-GPCR biology, including the evolution and biochemistry of adhesion-GPCRs; there are extensive discussions on the functional nature of these receptors during development, the immune response and tumourgenesis. Finally, there are chapters dedicated to adhesion-GPCR signalling, an area of intense investigation. This volume focuses on the recent advances in adhesion-GPCR biology.

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Includes evolution of the adhesion-GPCR genes in several speciesExplores how this proteolytic cleavage was identified as an intrinsic protein modification process in the majority adhesion-GPCRsDescribes the expression of adhesion-GPCRs within the male reproductive tract and reviews their potential contribution in reproductive competence


THE ADHESION GPCRs; GENE REPERTOI RE, PHYLOGENY AND EVOLUTION.- 7tm?CADHERINS: Developmental Roles and Future Challenges.- LATROPHILIN SIGNALLING IN TISUE POLARITY AND MORPHOGENESIS.- GPS Proteolytic Cleavage of Adhesion?GPCRs.- THE LATROPHILINS, "SPLIT?PERSONALITY" RECEPTORS.- Studies on the Very Large G Protein?Coupled Receptor: From Initial Discovery to Determining Its Role in Sensorineural Deafness in Higher Animals.- Adhesion?GPCRs in the CNS.- GPR56 Interacts withExtracellular Matrix and Regulates Cancer Progression.- Adhesion?GPCRs in Tumorigenesis.- Immunity and adhesion?GPCRs.- CD97 IN LEUKOCYTE TRAFFICKING.- THE ROLE OF CD97 IN REGULATING ADAPTIVE  T?CEL RESPONSES.- F4/80: The Macrophage?Specific Adhesion?GPCR and Its Role in Immunoregulation.- Signal transduction mediated through adhesion?GPCRs.- EMERGING ROLES OF BRAIN?SPECIFIC ANGIOGENESIS INHIBITOR 1.- Appendix: Mammalian

Über den Autor

Simon Yona, PhD, graduated from Kings College, University London with a BSc in Physiology and a MSc in Pharmacology, before completing a PhD with Prof. R.J. Flower FRS and Prof. M. Perretti, at St. Bartholomew's Hospital, University of London. Following his doctorate Simon took up a Postdoctoral Research position with Prof. S. Gordon FRS, at the Sir William Dunn School of Pathology, University of Oxford, where he investigated the roles and functions of the leukocyte restricted adhesion-GPCRs. Dr. Yona moved from Oxford to join the group of Prof. S. Jung, at the Weizmann Institute of Science, Rehovot, when he was awarded a Federation of European Biochemical Societies, International Fellowship. Currently he is investigating the developmental profile of mononuclear phagocytes in a number of pathologies. Martin Stacey, DPhil (Oxon), graduated from Hertford College, University of Oxford with an MBiochem before completing a DPhil in the laboratory of Prof. S. Gordon FRS. He continued working at the Sir William Dunn School of Pathology for a number of years where he cloned and characterized leukocyte adhesion-GPCRs and demonstrated the existence of their cell surface ligands. More recently, Dr. Stacey has been appointed as a Lecturer of Immunology, at the University of Leeds where his laboratory focuses on adhesion-GPCRs and role of myeloid cells in human disease.

ISBN 1-441979-12-3, ISBN 1-44-197912-3, ISBN 1-44197-912-3, ISBN 1-441-97912-3, ISBN 1-4419-7912-3

ISBN 978-1-441979-12-4, ISBN 978-1-44-197912-4, ISBN 978-1-44197-912-4, ISBN 978-1-441-97912-4, ISBN 978-1-4419-7912-4

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