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Harris, Tony (Herausgeber)

Adherens Junctions: from Molecular Mechanisms to Tissue Development and Disease (Gebundene Ausgabe)


Reihe: Subcellular Biochemistry 60

Springer-Verlag GmbH, Springer Netherland, Juni 2012


431 S. - Sprache: Englisch - 57 farbige Abbildungen, 5 schwarz-weiße Tabellen - 244x164x25 mm Book

ISBN: 9400741855 EAN: 9789400741850

Cell-cell adhesion is fundamental for the development and homeostasis of animal tissues and organs. Adherens junctions (AJs) are the best understood cell-cell adhesion complexes. In this volume, a group of internationally recognized experts reviews AJ biology over a wide range of organization; from atoms to molecules, to protein complexes, molecular networks, cells, tissues, and overall animal development. AJs have also been an integral part of animal evolution, and play central roles in cancer development, pathogen infection and other diseases. This book addresses major questions encompassing AJ biology. . How did AJs evolve? . How do cadherins and catenins interact to assemble AJs and mediate adhesion? . How do AJs interface with other cellular machinery to couple adhesion with the whole cell? . How do AJs affect cell behaviour and multicellular development? . How can abnormal AJ activity lead to disease?


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Produktdetails

Up-to-date reviews of adherens junction biology from internationally recognized experts in the field Covers adherens junction biology from atoms to overall animal development and disease A comprehensive resource for the research laboratory A comprehensive teaching tool for advanced undergraduate and graduate courses in cell and developmental biology Valuable for both newcomers and experts in the field

Inhaltsverzeichnis

1. An introduction to adherens junctions: from molecular mechanisms to tissue development and disease; Tony HarrisPart I: How AJs evolved 2. Evolution of the cadherin-catenin complex; Hiroki OdaPart II: How cadherins and catenins interact to assemble AJs 3. The three-dimensional structure of the cadherin-catenin complex; Noboru Ishiyama and Mitsuhiko Ikura 4. Biophysics of cadherin adhesion; Deborah Leckband and Sanjeevi Sivasankar 5. Adherens junction assembly; Sergey TroyanovskiPart III: How AJs interface with other cellular machinery 6. The cytoskeleton and classical cadherin adhesions; Siew Ping Han and Alpha Yap 7. Immunoglobulin superfamily receptors and adherens junctions; Yohei Shimono, Yoshiyuki Rikitake, Kenji Mandai, Masahiro Mori and Yoshimi Takai 8. Signaling from the adherens junction; Abbye McEwen, David Escobar and Cara Gottardi 9. Adherens junction turnover: regulating adhesion through cadherin endocytosis, degradation, and recycling; Benjamin Nanes and Andrew KowalczykPart IV: How AJs affect cell behaviour and multicellular development 10. Adherens junctions during cell migration; Sandrine Etienne-Manneville 11. Adherens junctions and cadherins in Drosophila development; Annalisa Letizia and Marta Llimargas 12. Adherens junctions in C. elegans embryonic morphogenesis; Stephen Armenti and Jeremy Nance 13. Cadherin function during Xenopus gastrulation; Rudolf Winklbauer 14. Adherens junctions in mammalian development, homeostasis and disease: lessons from mice; Barbara Boggetti and Carien NiessenPart V: How AJs affect tissue homeostasis and disease 15. Adherens junctions and stem cells; Terry Lechler 16. Adherens junctions and cancer; Valeri Vasioukhin 17. Adherens junctions and pathogens entry; Georgios Nikitas and Pascale CossartIndex


ISBN 9-400741-85-5, ISBN 9-40-074185-5, ISBN 9-40074-185-5, ISBN 9-400-74185-5, ISBN 9-4007-4185-5

ISBN 978-9-400741-85-0, ISBN 978-9-40-074185-0, ISBN 978-9-40074-185-0, ISBN 978-9-400-74185-0, ISBN 978-9-4007-4185-0

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