Targeting Functional Centers of the Ribosome (Hardcover)

Name: Targeting Functional Centers of the Ribosome
Author: Chen Davidovich

von Chen Davidovich Verlag: Springer Berlin

2011 - Erschienen 03.02.2011 - Gebunden, 88 Seiten, 241mm x 160mm x 9mm, Sprache(n): eng

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Nominated by the Weizmann Institute, Israel for a Springer Theses PrizeThis research has already led to attempts to improve PTC antibioticsBased on these findings further research into designing a functional construct mimicking a functional proto-ribosome has been initiatedIncludes supplementary material: sn.pub/extras

This thesis describes research into the mode of function, inhibition, and evolution of the ribosomal catalytic center, the Peptidyl Transferase Center (PTC)--research that has already led to attempts at improving PTC antibiotics. The PhD candidate carried out two parallel studies. One using a combination of X-ray crystallography, biochemistry, molecular biology, and theoretical studies to obtain crystal structures of ribosomal particles with antibiotics that target the PTC, revealing the modes of action, resistance, cross-resistance and discrimination between ribosomes of eubacterial pathogens and eukaryotic hosts. In the second parallel study, the candidate synthesized a ribosomal substructure--one that may represent the minimal entity capable of catalyzing peptide bond formation--shedding light on the origin of the ribosome itself.

Produktart:

📚 Bücher

Anbieter:

MARZIES Buch- und Medienhandel

Bestell-Nr.:

A12525092

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ISBN:

3642169309

EAN: